Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Nature: Oct 27, 2011

In Nature this week, an international team led by investigators at Brown University reports its analysis of multiple phylogenomic data sets for mollusks — "containing up to 216,402 sites and 1,185 gene regions using multiple models and methods." The team unearthed evidence to "support the clade Aculifera, containing the three molluscan groups with spicules but without true shells, and … the monophyly of Conchifera." Overall, the team says its study will support further investigations into mollusk evolution.

Elsewhere, an international team led by researchers at the University of Melbourne reports a draft genome of the parasite Ascaris sum, which it compared with other nematode genomes. The team says its study "provides a comprehensive resource to the scientific community and underpins the development of new and urgently needed interventions (drugs, vaccines, and diagnostic tests) against ascariasis and other nematodiases." Our sister publication GenomeWeb Daily News has more on this study.

The University of Texas Southwestern Medical Center's Anthony Orvedahl and his colleagues report in a Nature paper published online in advance on their "high-content, image-based, genome-wide small interfering RNA screen to detect genes required for the co-localization of Sindbis virus capsid protein with autophagolysosomes." Of the 141 candidate genes required for viral autophagy the researchers identified, 96 are "also required for Parkin-mediated mitophagy, indicating that common molecular determinants may be involved in autophagic targeting of viral nucleocapsids and autophagic targeting of damaged mitochondria," they write.

Over in Nature Genetics, a team led by investigators at the King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia, shows that a "loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus." Further, the researchers report evidence to confirm the previously reported "confirm the critical role of impaired clearance of degraded DNA in SLE pathogenesis," they write.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.