In Nature this week, researchers at Rockefeller University in New York say intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway. The researchers generated humanized DC-SIGN mice to demonstrate that the anti-inflammatory activity of immunoglobulin can be recreated by the transfer of bone-marrow-derived sFc-treated hDC-SIGN+ macrophages or dendritic cells into naive recipients.