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In a paper published online in advance in Nature this week, investigators at the Wellcome Trust Genome Campus and elsewhere report their creation of a "high-throughput gene-targeting pipeline for the generation of reporter-tagged, conditional alleles," with which to interrogate mouse gene functions. To date, the team has produced more than 12,000 vectors and 9,000 conditional, targeted alleles in "highly germline-competent C57BL/6N embryonic stem cells," it writes.

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