In a paper published online in advance in Nature this week, investigators at ETH Zürich's Institute of Molecular Biology and Biophysics report crystal structures for the Saccharomyces cerevisiae chromatin remodeling factor ISW1a "lacking its ATPase domain both alone and with DNA bound." In combining the composite X-ray and electron microscopy structures, and employing site-directed photocrosslinking analyses of these ISW1a complexes, the team found evidence that suggests "how a chromatin remodeling factor