In a paper published online in advance in Nature this week, an international team led by investigators at Imperial College London shows that the homing endonuclease gene I-Sce1 "can substantially increase its transmission to the progeny in transgenic mosquitoes of the human malaria vector Anopheles gambiae." More specifically, I-Sce1 quickly invades mosquito populations such that it validates mathematical models of homing endonuclease gene transmission dynamics.