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In a paper published online in advance in Nature this week, MIT's Tyler Jacks and his colleagues describe the "suppression of lung adenocarcinoma progression by Nkx2-1," the NK2-related homeobox transcription factor. In a KrasLSL-G12D/+;p53flox/flox mouse model, the team found that "Nkx2-1 negativity is pathognomonic of high-grade poorly differentiated tumors." In their subsequent gain- and loss-of-function manipulations, the researchers found that the transcription factor controls tumor differentiation but also limits its metastatic potential.

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Russia says its candidate SARS-CoV-2 vaccine has a very high efficacy rate in an initial analysis of clinical trial data, according to the Financial Times.

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