This Week in Nature

In a paper published online in advance in Nature this week, MIT's Tyler Jacks and his colleagues describe the "suppression of lung adenocarcinoma progression by Nkx2-1," the NK2-related homeobox transcription factor. In a KrasLSL-G12D/+;p53flox/flox mouse model, the team found that "Nkx2-1 negativity is pathognomonic of high-grade poorly differentiated tumors." In their subsequent gain- and loss-of-function manipulations, the researchers found that the transcription factor controls tumor differentiation but also limits its metastatic potential.

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The New York City medical examiner is overseeing an effort to identify missing persons using DNA, according to the Associated Press.

Nobel laureate Günter Blobel has died at 81, the New York Times reports.

In PNAS this week: mouse model of genetically induced emphysema, gene expression signatures of circulating melanoma cells, and more.

Technology Review reports that 2017 was the year of consumer genetic testing and that it could spur new analysis companies.