This Week in Nature

In a paper published online in advance in Nature this week, an international team led by investigators at Umeå University in Sweden describes a "novel pathway of small guide RNA maturation and the first example of a host factor — RNase III — required for bacterial RNA-mediated immunity against invaders." Using RNA-seq on Streptococcus pyrogenes, the team identified a "trans-encoded small RNA with 24-nucleotide complementarity to the repeat regions of crRNA precursor

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.