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In a paper published online in advance in Nature this week, the Cold Spring Harbor Laboratory's Michael Wigler et al. report their use of whole-genome amplification and next-gen sequencing on flow-sorted nuclei isolated from polygenomic tumor cells to determine that, "in contrast to gradual models of tumor progression, our data indicate that tumors grow by punctuated clonal expansions with few persistent intermediates."

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NPR reports the US Food and Drug Administration has approved a treatment for a genetic disorder that causes rapid aging.

Late-stage testing indicates the AstraZeneca and Oxford University SARS-CoV-2 vaccine can have up to 90 percent efficacy, the Associated Press reports.

ScienceInsider reports Nature Communications is reviewing a paper on mentorship following social media criticism arguing it is sexist.

In PLOS this week: method to account for sequencing errors in phylogenies, study of influenza A in Switzerland, and more.