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This Week in Nature: Mar 8, 2007

It's a polar research issue of Nature, but there are still some 'omic papers scattered about.

A publication from lead author Christopher Greenman at the Wellcome Trust Sanger Institute presents data from a large-scale cancer sequencing effort that turned up more than 1,000 unknown mutations linked to tumor formation. There's also a news and views article paired with the paper and written by Daniel Haber and Jeff Settleman from Massachusetts General Hospital Cancer Center.

In another paper, lead author Chris Organ from Harvard and his team analyze genome size in dinosaurs. They demonstrate a new method for estimating genome size and use it to predict this measure in 31 species of dinosaurs.


The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.