This Week in Nature

In a paper published online in advance in Nature this week, members of the Wellcome Trust Sanger Institute's Cancer Genome Project, along with their international colleagues, report that the SWI/SNF chromatin remodeling complex gene PBRM1 is frequently mutated in renal carcinomas. By sequencing the exomes in a series of primary clear cell carcinomas, the CGP-led team found truncating mutations in PBRM1 in 41 percent of cases.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.