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In a paper published online in advance in Nature this week, members of the Wellcome Trust Sanger Institute's Cancer Genome Project, along with their international colleagues, report that the SWI/SNF chromatin remodeling complex gene PBRM1 is frequently mutated in renal carcinomas. By sequencing the exomes in a series of primary clear cell carcinomas, the CGP-led team found truncating mutations in PBRM1 in 41 percent of cases.

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