In a paper published online in advance in Nature this week, researchers at the Children's Hospital of Philadelphia, along with their international colleagues, show that "common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma." In a genome-wide association study of 2,251 patients and 6,097 controls, the CHOP-led team found an enriched signal at LMO1 in individuals who had the most aggressive neuroblastomas.