This Week in Nature

In a paper published online in advance in Nature this week, a team led by researchers at Oregon Health and Science University describes "ploidy conveyor" as a source of genetic variation in hepatocytes. It shows that in mouse polyploidy hepatocytes, multipolar mitotic spindles frequently form — which "can result in one-step ploidy reversal to generate offspring with halved chromosome content," the team writes.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.