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In a paper published online in advance in Nature this week, a team led by researchers at Oregon Health and Science University describes "ploidy conveyor" as a source of genetic variation in hepatocytes. It shows that in mouse polyploidy hepatocytes, multipolar mitotic spindles frequently form — which "can result in one-step ploidy reversal to generate offspring with halved chromosome content," the team writes.

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An analysis of blood donations suggests SARS-CoV-2 was present in the US weeks earlier than thought, according to NPR.

The Guardian reports that DeepMind Technologies' AlphaFold can predict how proteins fold.

CNBC reports that a US Centers for Disease Control and Prevention advisory panel is to vote on how to distribute COVID-19 vaccines.

In PNAS this week: targeting progesterone signaling in ovarian cancer, LINE-1 retrotransposition events in adenocarcinomas, and more.