In the advance, online edition of Nature Biotechnology this week, researchers from Germany and Singapore examined the how gene expression shifts when the malarial parasite Plasmodium falciparum is exposed to 20 compounds that inhibit an early stage of the parasite's development in blood cells. The team found at least three-fold changes in the expression of roughly 59 percent of P. falciparum coding genes after treatment with one or more of the chemicals.