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In Nature this week, scientists led by HHMI's Raymond Deshaies describe the polyubiquitylation pathway, which is the conjugation of a series of ubiquitin molecules onto proteins as part of the degradation process. By employing "new theoretical and experimental methodologies," they were able to watch the process in milliseconds, and found that it actually proceeds sequentially.

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Bloomberg reports AstraZeneca may conduct another study of its candidate SARS-CoV-2 vaccine after dosing error.

Moderna is applying for an Emergency Use Authorization for its coronavirus vaccine, according to the New York Times.

The National Health Service is to conduct a trial of Grail's blood-based screening test for cancer.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.