This Week in Nature

In Nature this week, scientists led by HHMI's Raymond Deshaies describe the polyubiquitylation pathway, which is the conjugation of a series of ubiquitin molecules onto proteins as part of the degradation process. By employing "new theoretical and experimental methodologies," they were able to watch the process in milliseconds, and found that it actually proceeds sequentially.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.