This Week in Nature

In early online publication in Nature, Harvard's Bill Hahn is senior author on work that used an RNAi screen to find synthetic lethal partners of oncogenic KRAS -- "gene products that, when inhibited, result in cell death only in the presence of an oncogenic allele." They found that the IkappaB kinase TBK1 was needed in cells with mutant KRAS, and by suppressing this gene they induced apoptosis in human cancer cells that depend on oncogenic KRAS expression.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.