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This Week in Nature

There's a silver lining to this downturn, and John Browning touches on it in an essay in this week's issue of Nature. "Venture funding is declining quickly and is unlikely to bounce back," he writes. "But less money means lower expectations – good news for smaller science start-ups." While the 1990s boom meant expectations that many companies couldn't meet, today's market gives smaller, less ambitious projects a better chance.

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Researchers tie a variant in ADAMTS3 to breathing difficulties in dissimilar dog breeds, according to Discover's D-brief blog.

The Japan Times reports that researchers sequenced the genome of a woman who lived during the Jomon period.

Parents of children with rare genetic disease have to contend with shifts in the interpretation of genetic variants, the Wall Street Journal reports.

In Science this week: single-nucleus RNA sequencing of brain tissue from individuals with autism, and more.