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In the current issue of Nature, scientists led by the University of Pennsylvania's Shelley Berger used chIP to study how Sir2 in yeast, which is known to deacetylate histone H4 lysine 16 and play a role in aging, affects cellular longevity. She found that in old yeast cells, a decrease in Sir2 was met by an increase in H4 lysine 16 acetylation and loss of histones at specific subtelomeric regions, resulting in "compromised transcriptional silencing at these loci."

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The Washington Post reports that Herbert Tabor, who worked at the US National Institutes of Health for 77 years, has died at 101.

The World Bank is seeking approval for a $12 billion plan to provide low-income nations with funds to procure SARS-CoV-2 vaccines, according to Reuters.

Science writes that public health officials and others are debating whether cycle threshold values should be included on SARS-CoV-2 results.

In Nucleic Acids Research this week: online database of SARS-CoV-2 protein structures, atlas of the human brain, and more.