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Published in Nature's early online edition, researchers at Children's Hospital Boston have used stem cells to study why cancer appears less in people with Down syndrome. Following up on previous studies, they found that one gene on chromosome 21, DSCR1, is increased in expression in Down's syndrome tissues and in a mouse model of Down's syndrome. DSCR1, Down's syndrome candidate region-1, encodes a protein that suppresses angiogenesis by the calcineurin pathway.

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