This Week in Nature

Published in Nature's early online edition, researchers at Children's Hospital Boston have used stem cells to study why cancer appears less in people with Down syndrome. Following up on previous studies, they found that one gene on chromosome 21, DSCR1, is increased in expression in Down's syndrome tissues and in a mouse model of Down's syndrome. DSCR1, Down's syndrome candidate region-1, encodes a protein that suppresses angiogenesis by the calcineurin pathway.

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23andMe's Anne Wojcicki ponders DNA and what it means to be human in a New York Times essay.

A new estimate places the last universal common ancestor to life on Earth as living 3.9 billion years ago, Inverse reports.

In PNAS this week: retinitis pigmentosa gene therapy, role of microbiome in growth stunting, and more.

Bloomberg reports that researchers and drug companies are modeling anti-obesity treatments after the rare genetic condition essential fructosuria.