This Week in Nature

In early online, UCSD's Bing Ren used chIP-chip to locate promoters, enhancers, and insulators across the human genome in multiple cell types. They found over 55,000 potential transcriptional enhancers, and that while the chromatin state at promoters and CTCF-binding at insulators doesn't change much across cell types, enhancers show highly cell-type-specific histone modification patterns and genome-wide, cell-type-specific gene expression programs.

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