Nature hits the newsstands today, which means we hit the books to bring you our weekly round-up of articles worth reading. In news this week, the magazine checks in on metabolomics. It's déjà vu all over again: according to the article, the newest 'omics could very well offer the promise of medical success "where genomics and proteomics have failed." Another news item delves into data-sharing websites -- specifically, Swivel and IBM's Many Eyes -- where scientists can upload their data to enable their peers to analyze and visualize them with new approaches. And in a paper today, scientists at Johns Hopkins University and the University of California, San Diego, report on studies using microfluidics and computational modeling to analyze gene expression and phenotype in the yeast mating pathway and note the importance of MAPK regulation.