Spanish researchers used transcriptome sequencing to uncover molecular subtypes of chronic lymphocytic leukemia with notable clinical characteristics — work they describe online in Genome Research. The team did deep RNA sequencing on normal B cell sub-populations and tumor samples from nearly 100 individuals with CLL.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.