Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Genome Research : Aug 1, 2012

In a Genome Research preprint published online this week, Stanford University's Andrew Fire and his colleagues report on their use of high-throughput ribosome profiling "to analyze detailed translational parameters for five well-studied targets of miRNAs that function in the C. elegans heterochronic pathway." Fire et al. report having found evidence to support "models in which physiological regulation by this set of C. elegans miRNAs derives from combinatorial effects including suppressed recruitment/activation of translational machinery, compromised stability of target messages, and post- or peri-translational effects on the lifetime of polypeptide products."

Tohoku University's Takashi Makino and the University of Dublin's Aoife McLysaght present evidence of biased gene loss after whole-genome duplication, lending support to the "hypothesis of biologically significant gene clusters in eukaryotic genomes." Makino and McLysaght add that their "observations give us new insight for understanding the evolution of genome structure and of protein interaction networks."

In another Genome Research paper published online in advance, researchers at Mater Hospital in Sydney and at the University of Queensland characterize the KLF1-dependent erythroid transcriptome using mRNA-seq data for both Klf1+/+ and Klf1-/- tissue. The authors say that their study "has revealed novel target genes not previously obtainable by traditional microarray technology and provided novel insights into the function of KLF1 as a transcriptional activator." They add that they've "identified two novel lncRNAs that are dynamically expressed during erythroid differentiation and discovered a role for KLF1 in directing apoptotic gene expression to drive the terminal stages of erythroid maturation."

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.