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This Week in Genome Research : Aug 1, 2012

In a Genome Research preprint published online this week, Stanford University's Andrew Fire and his colleagues report on their use of high-throughput ribosome profiling "to analyze detailed translational parameters for five well-studied targets of miRNAs that function in the C. elegans heterochronic pathway." Fire et al. report having found evidence to support "models in which physiological regulation by this set of C. elegans miRNAs derives from combinatorial effects including suppressed recruitment/activation of translational machinery, compromised stability of target messages, and post- or peri-translational effects on the lifetime of polypeptide products."

Tohoku University's Takashi Makino and the University of Dublin's Aoife McLysaght present evidence of biased gene loss after whole-genome duplication, lending support to the "hypothesis of biologically significant gene clusters in eukaryotic genomes." Makino and McLysaght add that their "observations give us new insight for understanding the evolution of genome structure and of protein interaction networks."

In another Genome Research paper published online in advance, researchers at Mater Hospital in Sydney and at the University of Queensland characterize the KLF1-dependent erythroid transcriptome using mRNA-seq data for both Klf1+/+ and Klf1-/- tissue. The authors say that their study "has revealed novel target genes not previously obtainable by traditional microarray technology and provided novel insights into the function of KLF1 as a transcriptional activator." They add that they've "identified two novel lncRNAs that are dynamically expressed during erythroid differentiation and discovered a role for KLF1 in directing apoptotic gene expression to drive the terminal stages of erythroid maturation."

The Scan

Rise of BA.5

The New York Times reports that the Omicron subvariant BA.5 has become the dominant version of SARS-CoV-2 in the US.

UK Health Secretary Resigns

Sajid Javid, the UK health secretary, resigned along with Chancellor Rishi Sunak, saying they cannot work with Prime Minister Boris Johnson's government, CNN reports.

Clones From Freeze-Dried Cells

A team in Japan has cloned mice from freeze-dried skin cells, according to the Guardian.

Genome Research Papers on Craniosynostosis, Macaque Retrotransposition, More

In Genome Research this week: structural variants in craniosynostosis, LINE-1 activity in rhesus macaque brain, and more.