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This Week in Genome Research: Jun 27, 2012

In a paper published online in advance in Genome Research this week, researchers at the Weizmann Institute of Science report having reconstructed the content of the CRISPR bacterial immune system in the human gut microbiomes of 124 European individuals, and then having used that "to identify a catalogue of 991 phages targeted by CRISPR across all individuals," they write. The Weizmann team reports that "a significant fraction of phages … are shown to exist in fecal samples previously derived from American and Japanese individuals, identifying a common reservoir of phages frequently associated with the human gut microbiome." Overall, the team says, its results "imply that phage-bacterial attack-resistance interactions occur within the human gut microbiome, possibly affecting microbiota composition and human health."

And in another paper published online in advance, the California Institute of Technology's Barbara Wold and her colleagues report on their construction of global functional maps to identify regulatory targets of unc-120 or hlh-1 — two major regulators of Caenorhabditis elegans body wall muscle differentiation — via RNA-seq, to determine HLH-1 occupancy using ChIP-seq, and to identify additional HLH-1 collaborating transcription factors. Overall, Wold et al. report having found "760 genes [that] are significant regulatory targets of both hlh-1 and unc-120, but each factor has a larger number of unique targets." Further, the researchers showed that strongly tissue-specific factors broadly contribute to the transcriptional output of muscle tissue in the nematode.

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.