Investigators at Stockholm University and their colleagues show in a Genome Research paper published online in advance this week that adenosine to inosine editing of miRNAs increases in the mouse brain during development, and that it "gradually changes the proportions of the two miR-376a isoforms." Further, "by comparing editing of pre-miRNA with editing and expression of the corresponding mature miRNA, we also show an editing induced developmental regulation of miRNA express

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