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This Week in Genome Research: Mar 7, 2012

In a paper published online in advance in Genome Research this week, a team led by investigators at Johns Hopkins School of Medicine shows that "DNA-hypermethylation preferentially targets the subset of PcG genes that are developmental regulators, and this may contribute to the stem-like state of cancer." The team also says that "the capacity for global methylation profiling to cluster tumors by phenotype may have important implications for further refining tumor behavior patterns that may ultimately aid therapeutic interventions."

The Medical University of Vienna's Yamile Marquez and her colleagues report having sequenced and mapped at high-coverage an Arabidopsis transcriptome, through which they detected approximately 150,000 splice junctions "derived mostly from typical plant introns, including an eight-fold increase in the number of U12 introns." In addition, the team identified "extensive AS [alternative splicing] coupled to nonsense-mediated decay in AFC2, encoding a highly conserved LAMMER kinase which phosphorylates splicing factors, thus establishing a complex loop in AS regulation."

The Scan

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.