Researchers at the University of North Carolina, Chapel Hill, report in a paper published online in advance in Genome Research that the "tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription." More specifically, the team reports its generation of an experimental system in which they addressed "questions regarding the genomic mechanisms by which chimeric transcription factors cause cancer" using EWS-FLI and its parental transcription factor, FLI1.

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Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.

Retraction Watch's Ivan Oransky and Adam Marcus report that Harvard Medical School and Brigham and Women's Hospital have recommended that more than 30 papers from a former researcher be retracted.

Thomas Steitz, who won the 2009 chemistry Nobel Prize for his ribosome work, has died, the Washington Post reports.

In PLOS this week: mechanisms for genes implicated in coronary artery disease, rumen microbes and host genetics influence cow methane production, and more.