Researchers at the University of North Carolina, Chapel Hill, report in a paper published online in advance in Genome Research that the "tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription." More specifically, the team reports its generation of an experimental system in which they addressed "questions regarding the genomic mechanisms by which chimeric transcription factors cause cancer" using EWS-FLI and its parental transcription factor, FLI1.

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