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This Week in Genome Research: Oct 19, 2011

In a paper published online in advance in Genome Research this week, a team led by investigators at the Broad Institute reports its characterization of colorectal carcinoma-associated microbiota by comparing whole-genome sequences from nine tumor-normal pairs. Using qPCR and 16S rDNA analysis, the team found that "Fusobacterium sequences were enriched in carcinomas."

In a related paper, researchers at the BC Cancer Agency and elsewhere in Canada report an association between the bacteria and colorectal carcinomas, saying that with an RNA-seq followed by host sequence subtraction approach, they "found marked over-representation of Fusobacterium nucleatum sequences in tumors relative to control specimens."

The Netherlands Cancer Institute's Jos Jonkers and his colleagues present shear-splink, an approach "for the semiquantitative high-throughput analysis of insertional mutations." The team also reports its launch of the Insertional Mutagenesis Database, a "publicly available Web-based application to analyze both retroviral- and transposon-based insertional mutagenesis data."

Uppsala University's Erik Axelsson and his colleagues show in a paper published online in advance in Genome Research this week that the "death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome." Moreover, the team says that "genetic determinants of recombination hotspots in the dog genome may ... reflect a fundamental process of relevance to diverse animal species."

The Scan

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.

Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer

A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis.

Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed

PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven.

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.