In a paper published online in advance in Genome Research this week, investigators at Washington University in St. Louis report on a method to characterize complex biomes based on in silico karyotyping, with which researchers are able to analyze "a defined representation of all DNA present in a sample." Biome representational in silico karyotyping, or BRISK as the team calls it, uses massively parallel sequencing on 27-mer DNAs per sample to deduce high-resolution karyotypes.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.