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In Genome Research this week, researchers in Australia suggest a recombination hotspot leads to sequence variability within the novel gene AK005651 and could contribute to an individual's susceptibility to type 1 diabetes. Sequence analysis of a series of congenic non-obese diabetic mouse strains and in 25 inbred strains revealed several haplotypes, including a unique non-obese diabetic haplotype associated with varying levels of type 1 diabetes susceptibility, the researchers write.

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