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In an early online article, scientists led by CSHL's Rob Martienssen have resequenced the fission yeast genome following mutagenesis to "readily identify a novel mutant involved in heterochromatic silencing." Candidate mutant genes were put back into a wild-type strain to reproduce the mutant phenotype, which allowed them to find an allele thatencodes an E2 ubiquitin ligase as being responsible for the swi*603 mutant phenotype.

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