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In Genome Research this week, European researchers used bead arrays and bisulfite sequencing to find methylation changes linked to systemic lupus erythrematosus in pairs of identical twins who were discordant for the autoimmune disease — especially at genes involved in immune function. Their follow-up experiments suggest those with lupus tend to have lower levels of 5-methylcytosine, less methylation at certain genes, and higher expression of these genes.

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The US Centers for Disease Control and Prevention has identified a small group of breakthrough COVID-19 cases, the Wall Street Journal reports.

The New York Times reports that the US Department of Defense is to use genetic genealogy approaches to identify the remains of unknown soldiers.

Vox and Nature discuss the importance of preparing for the next pandemic.

In Nature this week: comparison of five circulating tumor DNA assays, resequencing analysis of lettuce gives insight into its domestication, and more.