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In Genome Research this week, European researchers used bead arrays and bisulfite sequencing to find methylation changes linked to systemic lupus erythrematosus in pairs of identical twins who were discordant for the autoimmune disease — especially at genes involved in immune function. Their follow-up experiments suggest those with lupus tend to have lower levels of 5-methylcytosine, less methylation at certain genes, and higher expression of these genes.

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Moderna reports its vaccine is effective against new SARS-CoV-2 strains, though it is also developing a booster, according to the New York Times.

A new analysis suggests the B.1.1.7 strain of SARS-CoV-2 could be deadlier than previous ones, according to the Guardian.

NPR reports Merck is halting the development of its two candidate SARS-CoV-2 vaccines following disappointing Phase 1 results.

In PLOS this week: gene mutation linked to inherited venous thrombosis, lncRNA patterns in the Asian tiger mosquito, and more.