In the March issue of Genome Research, work led by Evan Eichler describes the first systematic and genome-wide analysis of segmental duplications and CNVs in the modern domesticated dog, Canis familiaris. Using tiling arrays that covered all predicted segmental duplications, Eichler's team performed array CGH across 17 breeds and a gray wolf, identifying 3,583 CNVs. They found that these CNVs span 429 genes that are involved in many biological processes such as olfaction, immunity, and gene regulation.

Get the full story

This story is free
for registered users

Registering provides access to this and other free content.

Register now.

Already have an account?
Login Now.