In Genome Biology this week, Lawrence Berkeley National Lab's Michael Eisen was lead author on a paper that identified a total of 21 transcription factors in the fruit fly that regulate embryo patterning and can bind to overlapping sets of thousands of genomic regions. The high overlap is interesting, the authors say, because the proteins belong to 11 binding domain families, program distinct fates, and can interact with DNA through different cis-regulatory modules.

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In Genome Biology this week: transcription factor use among brittle stars, single-cell RNA sequencing strategy, and more.