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This Week in Genome Biology: Jul 15, 2009

In Genome Biology this week, researchers at the University of New Mexico looked at patterns of gene duplication across the S. cerevisiae genome and compared them to those from C. elegans. Analyzing 68 duplication events in S. cerevisiae, they found whole genome duplications to be, for the most part, similar to small-scale duplication events in their "their structural attributes, the discernible length of the duplicated region as well as genomic location," they say in the abstract. Additionally, with respect to chromosomal location, extent of duplication, and the relative frequencies of complete, partial and chimeric duplications, they found notable differences in C. elegans gene duplicates.

In other work, Duke University scientists led by Uwe Ohler used a hierarchical clustering strategy and whole-genome tiling array time series data to construct a "comprehensive map of Drosophila TSSs and the conditions under which they are utilized," says the abstract. They were able to identify a set of 5,665 transcription start sites for approximately 4,000 genes and group them into two initiation patterns, peaked TSSs and broad TSS cluster groups.

Employing microarray gene expression analysis, scientists at the Shanghai Institutes for Biological Sciences studied the effects of haploid-expressed genes on noisier expression patterns. They found that, in X-linked genes, variable transcription isn't any different to that of autosomal genes but in autosomal genes where one allele is expressed while the other is silenced they do have "unusually high noise levels," they say. "These results suggest that high noise is not a necessary consequence of haploid expression and emphasize the primacy of expression level as a determinant of noise."

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.