Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Genome Biology: Apr 25, 2012

Researchers at the University of Massachusetts Medical School report on the combined experimental and bioinformatic approach they used "to identify and characterize origins of replication in three distantly related fission yeasts: Schizosaccharomyces pombe, Schizosaccharomyces octosporus, and Schizosaccharomyces japonicus" in a paper published online in advance in Genome Biology this week. The team mapped nucleosome occupancy by deep sequencing mononucleosomal DNA from the species, "finding that origins tend to occupy nucleosome-depleted regions," it writes.

In another paper published online in advance this week, a team led by investigators at the National Institute of Diabetes and Digestive and Kidney Diseases examines autosomal dosage compensation in Drosophila , reporting on its investigation of 21 DrosDel deficiency lines from chromosome arm 2L — a test set the researchers say "allowed us to look at one-dose genes in five regions with multiple deficiencies [to] explore the question of whether compensation is a property of individual genes or particular deficiencies." Overall, the team found that gene-specific dose responses vary. "Expression of two-dose genes that are first-degree neighbors of one-dose genes in novel network models also changed expression, and the directionality of change depended on the response of one-dose genes," the authors write.

Elsewhere in the journal, the Wellcome Trust Sanger Institute's David Adams and his colleagues present a computational approach to identify RNA editing sites by taking an initial set of transcriptome-genome mismatch sites and filtering those calls, accounting for systematic biases in alignment, single nucleotide variant calling, and sequencing depth.

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.