Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Genome Biology: Apr 25, 2012

Researchers at the University of Massachusetts Medical School report on the combined experimental and bioinformatic approach they used "to identify and characterize origins of replication in three distantly related fission yeasts: Schizosaccharomyces pombe, Schizosaccharomyces octosporus, and Schizosaccharomyces japonicus" in a paper published online in advance in Genome Biology this week. The team mapped nucleosome occupancy by deep sequencing mononucleosomal DNA from the species, "finding that origins tend to occupy nucleosome-depleted regions," it writes.

In another paper published online in advance this week, a team led by investigators at the National Institute of Diabetes and Digestive and Kidney Diseases examines autosomal dosage compensation in Drosophila , reporting on its investigation of 21 DrosDel deficiency lines from chromosome arm 2L — a test set the researchers say "allowed us to look at one-dose genes in five regions with multiple deficiencies [to] explore the question of whether compensation is a property of individual genes or particular deficiencies." Overall, the team found that gene-specific dose responses vary. "Expression of two-dose genes that are first-degree neighbors of one-dose genes in novel network models also changed expression, and the directionality of change depended on the response of one-dose genes," the authors write.

Elsewhere in the journal, the Wellcome Trust Sanger Institute's David Adams and his colleagues present a computational approach to identify RNA editing sites by taking an initial set of transcriptome-genome mismatch sites and filtering those calls, accounting for systematic biases in alignment, single nucleotide variant calling, and sequencing depth.

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.