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This Week in Genome Biology: Feb 29, 2012

The European Bioinformatics Institute's Tim Massingham and Nick Goldman present All Your Base, which they call "a fast and accurate probabilistic approach to base calling," in a paper published online in advance in Genome Biology this week. Massingham and Goldman say their approach "improves on the best existing base callers, especially when comparing the number of error-free reads." All Your Base is available online, here, they add.

In a another report published online in advance, Harvard University's Alexander Meissner and his colleagues report on the January Joint Keystone Symposium on Epigenomics and Chromatin Dynamics. The size of the meeting reflected "the excitement and many developments in this area," they write.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.