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This Week in Genome Biology : Feb 2, 2012

In a letter published online in advance in Genome Biology this week, members of the International Crocodilian Genomes Working Group announce their intention to sequence and assemble the American alligator, saltwater crocodile, and Indian gharial genomes. "We anticipate data collection and initial analyses to be complete by June 2012, and we plan to submit the genome paper within one year of finalizing these initial analyses," the team writes.

A team led by investigators at the University of Chicago this week report their use of a "Bayesian hierarchical model to estimate the enrichment of eQTLs [expression quantitative trait loci] in a wide variety of regulatory annotations" derived from 1,000 Genomes Project data. "We find that [approximately] 40 percent of eQTLs occur in open chromatin, and that they are particularly enriched in transcription factor binding sites, suggesting that many directly impact protein-DNA interactions," the authors write.

Elsewhere in Genome Biology, researchers at MIT present "MetaMerge, an algorithm for semi-automatically reconciling a pair of existing metabolic network reconstructions into a single metabolic network model." A team led by investigators at the Lawrence Berkeley National Laboratory describe "an integrated cross-species ontology consisting of over 6,500 classes representing a variety of anatomical entities, organized according to traditional anatomical classification criteria," dubbed Uberon. And researchers at Colorado State University present SpliceGrapher, "a method for predicting splice graphs that enhances curated gene models using evidence from RNA-Seq and EST alignments."

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.