Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Genome Biology: Nov 9, 2011

In a paper published online in advance in Genome Biology this week, the Centre for Genomic Regulation's Andre Minoche, Juliane Dohm, and Heinz Himmelbauer report their evaluation of sequencing data generated using Illumina's HiSeq and Genome Analyzer systems. In the team's experience, "GAIIx and HiSeq data sets show slightly different error profiles," and "quality filtering is essential to minimize downstream analysis artifacts" for both systems.

Yale University's Mark Gerstein and his team this week present a genome-wide analysis of chromatin features in yeast, through which the researchers identified histone modification-sensitive and -insensitive yeast transcription factors. The team says its method predicts "yeast transcription factor targets by integrating histone modification profiles with transcription factor binding motif information." This, the authors add, "shows improved predictive power compared to a binding motif-only method."

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.