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This Week in Genome Biology: Nov 9, 2011

In a paper published online in advance in Genome Biology this week, the Centre for Genomic Regulation's Andre Minoche, Juliane Dohm, and Heinz Himmelbauer report their evaluation of sequencing data generated using Illumina's HiSeq and Genome Analyzer systems. In the team's experience, "GAIIx and HiSeq data sets show slightly different error profiles," and "quality filtering is essential to minimize downstream analysis artifacts" for both systems.

Yale University's Mark Gerstein and his team this week present a genome-wide analysis of chromatin features in yeast, through which the researchers identified histone modification-sensitive and -insensitive yeast transcription factors. The team says its method predicts "yeast transcription factor targets by integrating histone modification profiles with transcription factor binding motif information." This, the authors add, "shows improved predictive power compared to a binding motif-only method."

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.