In a paper published online in advance in Genome Biology this week, the Centre for Genomic Regulation's Andre Minoche, Juliane Dohm, and Heinz Himmelbauer report their evaluation of sequencing data generated using Illumina's HiSeq and Genome Analyzer systems. In the team's experience, "GAIIx and HiSeq data sets show slightly different error profiles," and "quality filtering is essential to minimize downstream analysis artifacts" for both systems.

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