In a paper published online in Genome Biology this week, investigators at the Laboratoire de Microbiologie et Génétique Moléculaire in France present ISsaga, a Web application that "provides computational tools and methods for high-quality IS [insertion sequence] annotation." Using established insertion sequence annotation standards, ISsaga "permits rapid processing of single or multiple prokaryote genomes," and provides both a genomic context for single insertion sequences and a "graphical over

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