Published yesterday in Genome Biology, Chad Nusbaum at the Broad Institute is the lead author on a paper describing a novel method for closing non-structural gaps in the human genome. Even though the human genome is "finished," the most recent release contains 260 euchromatic gaps. In this work, they present an approach for closing these gaps using 454 sequencing, and as proof of principle, apply it to closing all three remaining non-structural gaps in chromosome 15.

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