In a paper published online in advance in Genome Biology, the Weizmann Institute of Science's Sivan Navon and Yitzhak Pilpel suggest that codon distribution along genes affects translation efficiency, which they deduced based on synthetic expression libraries in Escherichia coli. Overall, Navon and Pilpel say that their "study demonstrates how synthetic biology complements bioinformatics by providing a setup for well-controlled experiments in biology."