In a method paper published online in Genome Biology this week, the University of Washington's Jay Shendure and his colleagues describe an approach for shotgun fragment library construction based on high-density in vitro transposition. When applied to the sequencing of a human genome, Shedure et al. say their method produced coverage biases "comparable with conventional protocols," though it is more efficient than other methods.

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NPR reports that with medical data being big business, some companies want to get patients involved.

The Asbury Park Press reports on the startup Genomic Prediction's test to determine an embryo's risk of disease.

In PNAS this week: optical mapping allows glimpse of structural variants, disease-linked GATA2 mutations boosts its protein activity, and more.

Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.