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In Genome Biology this week, a team of researchers in Germany compared target genes of TFIIB and NC2 transcription factors in human B cells and analyzed the associated core promoter architectures. TFIIB occupancy is positively correlated with gene expression, the researchers write, and the majority of promoters are GC-rich and lack defined core promoter elements. They also found that NC2 binds to a highly related target gene set. "TFIIB and NC2 are global players that occupy active genes," the team writes.

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