In Genome Biology this week, a team of researchers led by investigators at the Baylor College of Medicine in Houston, Texas, report that anatomical similarities in divergent species are "accompanied by extensive transcriptome conservation." Using RNA sequencing, the team compared the abundance and developmental regulation of all transcripts in the amoebae Dictyostelium discoideum and Dictyostelium purpureum, which "have similar developmental morphologies although their genomes