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In Genome Biology this week, scientists led by Claes Wadelius at Uppsala University have used ChIP-seq to study the genome-wide DNA binding sites of FOXA1 and FOXA3 in HepG2 cells. Comparing their data to previous results for FOXA2, they found that these forkhead box/winged helix family member transcription factors often bind close to each other and that FOXA2 interacts with both FOXA1 and FOXA3 in vivo, while FOXA1 and FOXA3 do not appear to interact.

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