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In Genome Biology this week, two papers describe methods for sequence capture. In one, scientists led by Olivier Harismendy and Kelly Frazer at the University of California, San Diego, used oligo capture probes in solution to select for approximately 3.6 megabases of sequence target. The approach, they say, generated sequence data with sensitivity to detect 93 percent of SNPs with a calling accuracy greater than 99 percent.

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