Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Genome Biology: Apr 22, 2009

This week in Genome Biology, Japanese researchers performed the first genome-wide analysis of EGR-1 binding sites. While it's known that EGR-1 plays a role in monocytic differentiation, their technique allowed them to further describe how. Using ChIP-chip and combining the results with newly reported FANTOM4 data, they found that EGR-1 binding sites are "highly co-localized with CpG islands, acetylated histone H3 lysine 9 binding sites, and CAGE tag clusters," they write in the abstract.

Scientists also looked at the transcriptional features of genomic regulatory blocks. Combining CAGE tag mapping of transcription start sites, expression data, sequence, and epigenetic information, they found that GRB genes are different in that they have "longer CpG islands, a higher number and wider spacing of alternative transcription start sites, and a distinct composition of transcription factor binding sites in their core/proximal promoters."

Patrick Duffy at the University of Washington and the Seattle Biomedical Research Institute has trained high-throughput techniques on studying the malaria sporozoite. He and his team found that the malaria parasite sporozoite proteome changes during maturation, revealing proteins specifically expressed in the stage that infects the human host, he says in the abstract.

Josee Dostie's lab at McGill has developed a suite of computer programs for identifying genome-wide chromatin conformation signatures with 5C technology. In particular, they found that dynamic HoxA cluster chromatin conformation signatures are linked to cell differentiation, suggesting that these signatures could serve as novel disease biomarkers.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.