In Cell Metabolism this week, Francis Collins and his colleagues at the National Human Genome Research Institute provide a "global snapshot of the human islet epigenome," with which they've elucidated insights into type 2 diabetes susceptibility loci. By performing a genome-wide analysis of sites hypersensitive to DNAse I, the NHGRI-led team found around 18,000 putative promoters, several hundred of which were previously "unannotated and islet-active," the authors write.