This Week in Cell

Researchers from Harvard Medical School and Helicos BioSciences followed the half-lives of more than 21,000 messenger RNAs in yeast using the so-called anchor-away approach — a method that involves conditioning depleting cell nuclei of a polymerase II subunit component and then sequencing RNA in the cells as it became depleted. Based on their analysis of 21,248 transcript isoforms, the investigators identified variability in mRNA half-life, even amongst similar or identical isoforms.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.