This Week in Cell

Researchers from Harvard Medical School and Helicos BioSciences followed the half-lives of more than 21,000 messenger RNAs in yeast using the so-called anchor-away approach — a method that involves conditioning depleting cell nuclei of a polymerase II subunit component and then sequencing RNA in the cells as it became depleted. Based on their analysis of 21,248 transcript isoforms, the investigators identified variability in mRNA half-life, even amongst similar or identical isoforms.

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