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This Week in Cell: Mar 14, 2012

In a paper published online in advance in Molecular Cell this week, researchers at the University of Zurich show that poly(ADP-ribose)-polymerase-1, or PARP1/ARTD1, "is implicated in the maintenance of silent rDNA chromatin during cell division." More specifically, the team shows that "PARP1 associates with TIP5 … via the noncoding pRNA and binds to silent rRNA genes after their replication in mid-late S phase," such that it represses rRNA transcription and plays a role in the formation of silent rDNA chromatin. Overall, the Zurich team says its examination of the functions of PARP1 points to just "how epigenetic marks are transmitted during each cell cycle."

In the current issue of Cell, a team led by investigators at BGI-Shenzhen reports on its application of a high-throughput whole-genome single-cell sequencing method to two cells derived from a lymphoblastoid cell line. The team also "carried out whole-exome single-cell sequencing of 90 cells from a JAK2-negative myeloproliferative neoplasm patient." The BGI-led group says its sequencing data highlight "essential thrombocythemia-related candidate mutations such as SESN2 and NTRK1, which may be involved in neoplasm progression."

Another BGI-led team reports having performed single-cell exome sequencing on a clear cell renal cell carcinoma tumor and adjacent kidney tissue. "Analyses of these data allowed us to delineate a detailed intratumoral genetic landscape at a single-cell level," the authors write in Cell. "Our pilot study demonstrates that ccRCC [clear cell renal cell carcinoma tumor] may be more genetically complex than previously thought and provides information that can lead to new ways to investigate individual tumors, with the aim of developing more effective cellular targeted therapies."

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.