This Week in Cell

In a paper published online in advance in Molecular Cell this week, researchers at the University of Zurich show that poly(ADP-ribose)-polymerase-1, or PARP1/ARTD1, "is implicated in the maintenance of silent rDNA chromatin during cell division." More specifically, the team shows that "PARP1 associates with TIP5 … via the noncoding pRNA and binds to silent rRNA genes after their replication in mid-late S phase," such that it represses rRNA transcription and plays a role in the formation of silent rDNA chromatin.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.